Studies have shown that the health benefits of resveratrol and its derivative may be a result of their interactions with estrogen receptors, however, what is unclear is exactly which form or forms of the metabolized compound is most important, or even the relative importance of all of the metabolites together. A recent study by a group of collaborating scientists from the University of Parma, the University of Glasgow, and the University of Milan examined the interactions of resveratrol and its derivatives in the presence of human estrogen receptors; in hopes to gain further understanding of how exactly resveratrol in its various forms interacts on a chemical level in humans.
"If resveratrol is so structurally similar to DES, a harmful synthetic endocrine disruptor that is linked to a plethora of birth defects and health problems, how could it have such an opposite effect?”
"Could learning about the estrogenic activity of resveratrol help us understand the mechanisms of these more harmful synthetic endocrine disruptors? Additionally, could understanding the estrogen activity and mechanisms of resveratrol help us develop a sort of “antidote” to harmful endocrine disruptors?"
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