Last week at the annual joint meeting of the International
Society of Endocrinology and the Endocrine Society of Chicago, a team from Duke
University in North Carolina presented an abstract indicating that Bisphenol-A
(BPA) is linked to the speed of progression of inflammatory breast cancer as
well as rendering the treatment for the cancer less effective.
BPA, along with many other man-made chemicals, has become
quite prevalent in our environment, and have been shown to possess
estrogen-like characteristics which have led to significant human health problems. BPA, in addition to many similar endocrine
disruptors, can be found in many different products, including the plastic in water
bottles, the thermal paper for printers, and countless other products made from
plastic and epoxy resins.
Inflammatory breast cancer is much more aggressive and rare
compared with other cancers, and is also one of the more difficult cancers to
treat due to the fact that it is often not diagnosed until a much more advanced
stage.
Dr. Scott Sauer and his team from Duke University presented
their data at a recent meeting and found that BPA was the most active endocrine
disruptor in the breast cancer cells study, and BPA actually increases the rate
of inflammatory breast cancer cell growth and spread/proliferation. Specifically, BPA increased pEGFR and pERK
levels in EGFR-activated breast cancer cells, as well as increased expression
of a few antioxidants in these same cells, the levels of which are important in
the proliferation and spread the cancer.
A common treatment for inflammatory breast cancer,
lapatinib, basically functions to inhibit both pEGFR levels and GPER
expressions, however, this study by the Duke group found that BPA effectively
negated the actions of lapatinib, and basically rendered the drug
ineffective. In other words, BPA
increased pEGFR levels in the breast cancer cells much more quickly and
efficiently than the treatment drug could counteract, thereby indicating that
BPA not only can speed up the growth and spread of inflammatory breast cancer,
but it also makes the cells effectively resistant to the current therapy used
today.
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